Genetic Markers, Humoral Autoimmunity, and Prediction of Type 1 Diabetes in Siblings of A ffected Children
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منابع مشابه
Beta-cell Autoimmunity and Assessment of the Risk of Progression to Type 1 Diabetes
The purpose of this work was to assess the value of humoral and genetic risk markers in the prediction of type 1 diabetes in siblings of children with type 1 diabetes, to characterise preclinical course of beta-cell autoimmunity in siblings, and to investigate the frequency of autoantibodies and their relations to genetic markers, beta-cell function and progression to type 1 diabetes in a schoo...
متن کاملDynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study.
To study the dynamics of disease-associated humoral immune responses, we analyzed autoantibodies to the IA-2 protein (IA-2A), glutamic acid decarboxylase (GADA), and insulin (IAA) and also islet cell antibodies (ICA) in a population-based, prospective, representative series of 710 siblings (<20 years of age) of children with type 1 diabetes. Positivity for single autoantibodies was observed in ...
متن کاملHumoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes.
Type 1 diabetes mellitus (T1D) is an autoimmune disease encompassing the T-cell-mediated destruction of pancreatic β cells and the production of autoantibodies against islet proteins. In humoral autoimmunity in T1D, the detection of islet autoantibodies and the examination of their associations with genetic factors and cellular autoimmunity constitute major areas in both basic research and clin...
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Background: Type 1 diabetes is a disorder caused by autoimmune destruction of pancreatic insulin-producing cells. This induction of autoimmunity may be due to genetic and environmental factors. Bax and Bcl2 proteins play an important role in the process of apoptosis. Methods: In this study, 30 male Wistar rats weighting approximately 200±20gr were randomly selected from available rats in lab ...
متن کاملImmunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population.
The objective was to evaluate the prevalence and association of several markers (islet cell antibodies: ICA, insulin autoantibodies: IAA, glutamic acid decarboxylase antibodies: GADA and ICA512 antibodies: ICA512A) along with HLA DQB1 genotype in type 1 diabetes mellitus of recent onset, including siblings and individuals without any history of this disease, in an Argentine population. A total ...
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تاریخ انتشار 1999